Equine Cushing’s disease is a chronic, progressive endocrine disease seen in middle-aged to senior horses. More accurately labeled pituitary pars intermedia dysfunction, or PPID, this is a disease of the pituitary gland.
Anna O’Brien, DVM, discusses the pituitary gland, disease symptoms, diagnostics and caring for a Cushing’s horse.
Source: Horse Illustrated, January 23, 2021. Link. There is no cure for equine Cushing’s disease. However, pergolide (trade name Prascend), an FDA-approved medication, can manage the disease. Given orally once daily, it works to decrease the amount of ACTH in the blood.