Firocoxib is often prescribed to manage chronic pain and inflammation in horses, and its long-term use appears safe based on bloodwork. The drug is for once-daily use for up to 14 days, researchers on this study suggest firocoxib might be suitable for extended treatment in appropriate cases.
Source: The Horse, August 19, 2025. Link.
Veterinarians should evaluate horses individually and continue to monitor for adverse effects during long-term NSAID therapy.”