Research by Hal Schott, DVM, PhD, DACVIM, provides evidence that long-term treatment of PPID with pergolide, an oral medication, over a period of five years or greater produced clinical improvement in nearly all affected horses. His study examined 15 PPID positive horses over 9.5 years, with seven of those receiving a dosage increase from years 1.7 to 4.7. His research showed that the dosage increase may not be necessary.
Source: The Paulick Report, October 21, 2024. Link.