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A recently published study suggests that CBD+CBDA are each metabolized differently in dogs, with P450 enzymes, particularly CYP1A2 and CYP2C21, playing major roles with CYP1A2 being the likely primary metabolizer of CBD.
Pharmacodynamic modeling suggests minimal risk of significant interactions with other concomitantly used drugs at current dosing recommendations. Most importantly, CBD and CBDA does not alter activity of the multidrug resistant transporter showing that it should be safe for all dogs.” – Joseph J. Wakshlag, DVM, PhD
Source: Pet Business, September 2023. Link.
Also see: ElleVet Sciences receives patent for proprietary CBD+CBDA formulation, DVM 360, August 29, 2023. Link.