Natalie Voss’ article addresses why endometritis is difficult to combat in broodmares. However, the discussion of biofilms on tissues is interesting. Of particular note, some drug treatment combinations are counterproductive, effectively canceling out the benefits of the individual drugs.
Bacteria can’t “think” but can behave as though they have a herd mentality in a biofilm state. That’s why organisms often can’t clear infections on their own, and why antibiotic treatments often fail when fighting a biofilm.
Source: The Paulick Report, August 31, 2024. Link.
Biofilms aren’t just a uterine issue; really any chronic infection can involve a biofilm.”
Charts referenced: Practical diagnostics and therapeutics in bacterial endometritis, Clinical Theriogenology, September 2017. Link.